The use of CRISPR/Cas9 gene editing system in the treatment of HBV infection

Author : Medine Karadağ-Alpaslan
Number of pages : 1-7  


Hepatitis B disease is an infectious disease caused by the Hepatitis B virus (HBV) which may have different consequences such as cirrhosis and liver cancer. Although there is an effective vaccine against HBV, it is still a serious health problem for underdeveloped and some developing countries where the vaccination rate is low. Current treatments cannot clear all the viral infections. Therefore, there is an urgent need for definitive HBV treatment. The clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) method is frequently used in vitro and in vivo for genetic modifications, including targeting the HBV genome. Therefore, in this review, the use of CRISPR/Cas9 technology in the HBV genome for treatment purposes will be discussed with the aid of recent literature


cccDNA, CRISPR/Cas9, gene editing, HBV

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