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Abstract
Arthritis, a pervasive autoimmune disease globally, lacks a definitive cure, with current treatments primarily alleviating symptoms and slowing disease progression. However, the efficacy of existing therapies is curtailed by drug short lifespan and the need for frequent systemic administration, highlighting the potential of emerging gene therapies to revolutionize healthcare for arthritis. This overview explores recent advancements in gene therapy for arthritis, with a primary focus on rheumatoid arthritis (RA). Gene therapy has begun to be employed in RA treatment, utilizing novel vectors to enhance gene transfer efficiency and induce sustained, regulated gene expression in targeted tissues. Promising strides include the utilization of different serotypes of viral vectors, such as adeno-associated virus. Additionally, the review encompasses various gene transfer strategies, vector innovations, candidate genes, and safety considerations.
